|
KMID : 0358320070480040428
|
|
Korean Journal of Urology
2007 Volume.48 No. 4 p.428 ~ p.432
|
|
|
Efficacy and Safety of Uro-Vaxom Treatment for Patients with Recurrent Cystitis: An Open Multicenter Study
|
|
Lee Seung-Ju
Cho In-Rae
Lee Sang-Don
Kim Min-Eui
Shim Bong-Suk
Chung Byung-Ha
Chang Sung-Goo
Kim Hyung-Jin
Cho Yong-Hyun
Kim Chul-Sung
Kim Su-Jin
Woo Young-Nam
Kim Bup-Wan
Lee Jeong-Gu
|
|
|
Abstract
|
|
|
Purpose: We wanted to investigate the efficacy and safety of the immunotherapeutic Uro-Vaxom for treating uncomplicated recurrent cystitis in female patients only.
Materials & Methods: Adult female patients were enrolled in this multicenter, open-label study if they had acute cystitis at the enrollment visit and positive results on urine culture(≥103CFU/ml). The patients were treated for 3 months with one capsule daily of Uro-Vaxom after antibiotic therapy, and they were observed for another 3 months. The primary efficacy criteria were the cystitis recurrence rates over 6 months, the distribution of cystitis and the proportion of patients with cystitis.
Results: A total of 50 patients were evaluated. During the 6-month trial, the number of cystitis recurrences was significantly reduced in comparison with the 6-month pretrial period(on the average 0.64 as compared to 3.0 recurrences, respectively p＜0.001). The incidences of frequency, urgency and dysuria remained low until the end of the trial. Uro-Vaxom was well tolerated: side-effects were mentioned by 8% of the 50 patients, and there was no case leading to treatment withdrawal.
Conclusion: Uro-Vaxom significantly reduced the incidence of cystitis during the 6 months of this study, including the 3 months of treatment. These results demonstrate that Uro-Vaxom is a valuable agent for prophylaxis of recurrent cystitis. (Korean J Urol 2007;48:428-432)
|
|
|
KEYWORD
|
|
|
Female, Cystitis, Escherichia coli, Uro-Vaxom
|
|
|
FullTexts / Linksout information
|
|
  
|
|
|
Listed journal information
|
|
  
|